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Open Access Publications from the University of California

Collagen solubility correlates with skin optical clearing.

  • Author(s): Hirshburg, Jason
  • Choi, Bernard
  • Nelson, J Stuart
  • Yeh, Alvin T
  • et al.

Published Web Location Commons 'BY' version 4.0 license

Biomedical optics and photomedicine applications are challenged by the turbidity of most biological tissue systems. Nonreactive, biocompatible chemical agents can induce a reversible reduction in optical scattering of collagenous tissues such as human skin. Herein we show that a chemical agent's tissue optical clearing potential is directly related to its collagen solubility, providing a rational design basis for effective, percutaneous formulations.

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