Collagen solubility correlates with skin optical clearing.
- Author(s): Hirshburg, Jason
- Choi, Bernard
- Nelson, J Stuart
- Yeh, Alvin T
- et al.
Published Web Locationhttps://doi.org/10.1117/1.2220527
Biomedical optics and photomedicine applications are challenged by the turbidity of most biological tissue systems. Nonreactive, biocompatible chemical agents can induce a reversible reduction in optical scattering of collagenous tissues such as human skin. Herein we show that a chemical agent's tissue optical clearing potential is directly related to its collagen solubility, providing a rational design basis for effective, percutaneous formulations.