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The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
- Ehret, Georg B;
- Ferreira, Teresa;
- Chasman, Daniel I;
- Jackson, Anne U;
- Schmidt, Ellen M;
- Johnson, Toby;
- Thorleifsson, Gudmar;
- Luan, Jian'an;
- Donnelly, Louise A;
- Kanoni, Stavroula;
- Petersen, Ann-Kristin;
- Pihur, Vasyl;
- Strawbridge, Rona J;
- Shungin, Dmitry;
- Hughes, Maria F;
- Meirelles, Osorio;
- Kaakinen, Marika;
- Bouatia-Naji, Nabila;
- Kristiansson, Kati;
- Shah, Sonia;
- Kleber, Marcus E;
- Guo, Xiuqing;
- Lyytikäinen, Leo-Pekka;
- Fava, Cristiano;
- Eriksson, Niclas;
- Nolte, Ilja M;
- Magnusson, Patrik K;
- Salfati, Elias L;
- Rallidis, Loukianos S;
- Theusch, Elizabeth;
- Smith, Andrew JP;
- Folkersen, Lasse;
- Witkowska, Kate;
- Pers, Tune H;
- Joehanes, Roby;
- Kim, Stuart K;
- Lataniotis, Lazaros;
- Jansen, Rick;
- Johnson, Andrew D;
- Warren, Helen;
- Kim, Young Jin;
- Zhao, Wei;
- Wu, Ying;
- Tayo, Bamidele O;
- Bochud, Murielle;
- Absher, Devin;
- Adair, Linda S;
- Amin, Najaf;
- Arking, Dan E;
- Axelsson, Tomas;
- Baldassarre, Damiano;
- Balkau, Beverley;
- Bandinelli, Stefania;
- Barnes, Michael R;
- Barroso, Inês;
- Bevan, Stephen;
- Bis, Joshua C;
- Bjornsdottir, Gyda;
- Boehnke, Michael;
- Boerwinkle, Eric;
- Bonnycastle, Lori L;
- Boomsma, Dorret I;
- Bornstein, Stefan R;
- Brown, Morris J;
- Burnier, Michel;
- Cabrera, Claudia P;
- Chambers, John C;
- Chang, I-Shou;
- Cheng, Ching-Yu;
- Chines, Peter S;
- Chung, Ren-Hua;
- Collins, Francis S;
- Connell, John M;
- Döring, Angela;
- Dallongeville, Jean;
- Danesh, John;
- de Faire, Ulf;
- Delgado, Graciela;
- Dominiczak, Anna F;
- Doney, Alex SF;
- Drenos, Fotios;
- Edkins, Sarah;
- Eicher, John D;
- Elosua, Roberto;
- Enroth, Stefan;
- Erdmann, Jeanette;
- Eriksson, Per;
- Esko, Tonu;
- Evangelou, Evangelos;
- Evans, Alun;
- Fall, Tove;
- Farrall, Martin;
- Felix, Janine F;
- Ferrières, Jean;
- Ferrucci, Luigi;
- Fornage, Myriam;
- Forrester, Terrence;
- Franceschini, Nora;
- Franco, Oscar H;
- Franco-Cereceda, Anders;
- Fraser, Ross M;
- Ganesh, Santhi K;
- Gao, He;
- Gertow, Karl;
- Gianfagna, Francesco;
- Gigante, Bruna;
- Giulianini, Franco;
- Goel, Anuj;
- Goodall, Alison H;
- Goodarzi, Mark O;
- Gorski, Mathias;
- Gräßler, Jürgen;
- Groves, Christopher J;
- Gudnason, Vilmundur;
- Gyllensten, Ulf;
- Hallmans, Göran;
- Hartikainen, Anna-Liisa;
- Hassinen, Maija;
- Havulinna, Aki S;
- Hayward, Caroline;
- Hercberg, Serge;
- Herzig, Karl-Heinz;
- Hicks, Andrew A;
- Hingorani, Aroon D;
- Hirschhorn, Joel N;
- Hofman, Albert;
- Holmen, Jostein;
- Holmen, Oddgeir Lingaas;
- Hottenga, Jouke-Jan;
- Howard, Phil;
- Hsiung, Chao A;
- Hunt, Steven C;
- Ikram, M Arfan;
- Illig, Thomas;
- Iribarren, Carlos;
- Jensen, Richard A;
- Kähönen, Mika;
- Kang, Hyun Min;
- Kathiresan, Sekar;
- Keating, Brendan J;
- Khaw, Kay-Tee;
- Kim, Yun Kyoung;
- Kim, Eric;
- Kivimaki, Mika;
- Klopp, Norman;
- Kolovou, Genovefa;
- Komulainen, Pirjo;
- Kooner, Jaspal S;
- Kosova, Gulum;
- Krauss, Ronald M;
- Kuh, Diana;
- Kutalik, Zoltan;
- Kuusisto, Johanna;
- Kvaløy, Kirsti;
- Lakka, Timo A;
- Lee, Nanette R;
- Lee, I-Te;
- Lee, Wen-Jane;
- Levy, Daniel;
- Li, Xiaohui;
- Liang, Kae-Woei;
- Lin, Honghuang;
- Lin, Li;
- Lindström, Jaana;
- Lobbens, Stéphane;
- Männistö, Satu;
- Müller, Gabriele;
- Müller-Nurasyid, Martina;
- Mach, François;
- Markus, Hugh S;
- Marouli, Eirini;
- McCarthy, Mark I;
- McKenzie, Colin A;
- Meneton, Pierre;
- Menni, Cristina;
- Metspalu, Andres;
- Mijatovic, Vladan;
- Moilanen, Leena;
- Montasser, May E;
- Morris, Andrew D;
- Morrison, Alanna C;
- Mulas, Antonella;
- Nagaraja, Ramaiah;
- Narisu, Narisu;
- Nikus, Kjell;
- O'Donnell, Christopher J;
- O'Reilly, Paul F;
- Ong, Ken K;
- Paccaud, Fred;
- Palmer, Cameron D;
- Parsa, Afshin;
- Pedersen, Nancy L;
- Penninx, Brenda W;
- Perola, Markus;
- Peters, Annette;
- Poulter, Neil;
- Pramstaller, Peter P;
- Psaty, Bruce M;
- Quertermous, Thomas;
- Rao, Dabeeru C;
- Rasheed, Asif;
- Rayner, N William;
- Renström, Frida;
- Rettig, Rainer;
- Rice, Kenneth M;
- Roberts, Robert;
- Rose, Lynda M;
- Rossouw, Jacques;
- Samani, Nilesh J;
- Sanna, Serena;
- Saramies, Jouko;
- Schunkert, Heribert;
- Sebert, Sylvain;
- Sheu, Wayne H-H;
- Shin, Young-Ah;
- Sim, Xueling;
- Smit, Johannes H;
- Smith, Albert V;
- Sosa, Maria X;
- Spector, Tim D;
- Stančáková, Alena;
- Stanton, Alice V;
- Stirrups, Kathleen E;
- Stringham, Heather M;
- Sundstrom, Johan;
- Swift, Amy J;
- Syvänen, Ann-Christine;
- Tai, E-Shyong;
- Tanaka, Toshiko;
- Tarasov, Kirill V;
- Teumer, Alexander;
- Thorsteinsdottir, Unnur;
- Tobin, Martin D;
- Tremoli, Elena;
- Uitterlinden, Andre G;
- Uusitupa, Matti;
- Vaez, Ahmad;
- Vaidya, Dhananjay;
- van Duijn, Cornelia M;
- van Iperen, Erik PA;
- Vasan, Ramachandran S;
- Verwoert, Germaine C;
- Virtamo, Jarmo;
- Vitart, Veronique;
- Voight, Benjamin F;
- Vollenweider, Peter;
- Wagner, Aline;
- Wain, Louise V;
- Wareham, Nicholas J;
- Watkins, Hugh;
- Weder, Alan B;
- Westra, Harm-Jan;
- Wilks, Rainford;
- Wilsgaard, Tom;
- Wilson, James F;
- Wong, Tien Y;
- Yang, Tsun-Po;
- Yao, Jie;
- Yengo, Loic;
- Zhang, Weihua;
- Zhao, Jing Hua;
- Zhu, Xiaofeng;
- Bovet, Pascal;
- Cooper, Richard S;
- Mohlke, Karen L;
- Saleheen, Danish;
- Lee, Jong-Young;
- Elliott, Paul;
- Gierman, Hinco J;
- Willer, Cristen J;
- Franke, Lude;
- Hovingh, G Kees;
- Taylor, Kent D;
- Dedoussis, George;
- Sever, Peter;
- Wong, Andrew;
- Lind, Lars;
- Assimes, Themistocles L;
- Njølstad, Inger;
- Schwarz, Peter EH;
- Langenberg, Claudia;
- Snieder, Harold;
- Caulfield, Mark J;
- Melander, Olle;
- Laakso, Markku;
- Saltevo, Juha;
- Rauramaa, Rainer;
- Tuomilehto, Jaakko;
- Ingelsson, Erik;
- Lehtimäki, Terho;
- Hveem, Kristian;
- Palmas, Walter;
- März, Winfried;
- Kumari, Meena;
- Salomaa, Veikko;
- Chen, Yii-Der I;
- Rotter, Jerome I;
- Froguel, Philippe;
- Jarvelin, Marjo-Riitta;
- Lakatta, Edward G;
- Kuulasmaa, Kari;
- Franks, Paul W;
- Hamsten, Anders;
- Wichmann, H-Erich;
- Palmer, Colin NA;
- Stefansson, Kari;
- Ridker, Paul M;
- Loos, Ruth JF;
- Chakravarti, Aravinda;
- Deloukas, Panos;
- Morris, Andrew P;
- Newton-Cheh, Christopher;
- Munroe, Patricia B
Published Web Location
https://doi.org/10.1038/ng.3667Abstract
Patricia Munroe, Christopher Newton-Cheh, Andrew Morris and colleagues perform association studies in over 340,000 individuals of European ancestry and identify 66 loci, of which 17 are novel, involved in blood pressure regulation. The risk SNPs are enriched for cis-regulatory elements, particularly in vascular endothelial cells.
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