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Open Access Publications from the University of California

The how, why and clinical importance of stratum corneum acidification.

  • Author(s): Elias, Peter M
  • et al.

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In this article, I review the multiple endogenous mechanisms that contribute to the highly acidic pH of normal stratum corneum (SC). Then, I describe how each mechanism potentially impacts specific defensive functions of the SC. Finally, I review the rapidly expanding, clinical implications and potential therapeutic applications of SC acidification.

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