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Tuberculosis Molecular Bacterial Load Assay Reveals Early Delayed Bacterial Killing in Patients With Relapse
- Ntinginya, Nyanda Elias;
- Bakuli, Abhishek;
- Mapamba, Daniel;
- Sabiiti, Wilber;
- Kibiki, Gibson;
- Minja, Lilian Tina;
- Kuchaka, Davis;
- Reither, Klaus;
- Phillips, Patrick Peter John;
- Boeree, Martin Johan;
- Gillespie, Stephen H;
- Hoelscher, Michael;
- Heinrich, Norbert;
- Consortium, for the Pan African Consortium for the Evaluation of Antituberculosis Antibiotics
- et al.
Published Web Location
https://doi.org/10.1093/cid/ciac445Abstract
Bacterial killing in patients with tuberculosis (TB) relapse was compared to that in patients achieving cure, measured by TB molecular bacterial load assay (TB-MBLA) or mycobacteria growth indicator tube (MGIT) time to positivity (TTP). TB-MBLA in 4 relapsed patients was significantly different compared to 132 cured patients after 2 weeks of treatment; MGIT TTP showed a significant difference from week 8.
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