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Three-dimensional virtual microscopy of colorectal biopsies

  • Author(s): Wu, Mark L
  • Varga, V S
  • Kamaras, V
  • Ficsor, L
  • Tagscherer, A
  • Tulassay, Z
  • Molnar, B
  • et al.
Abstract

Conventional optical microscopy of specimens from colorectal biopsies commonly produces diagnostic errors due to incomplete sampling or poor orientation. Obtaining additional sections or re-embedding may help avoid these errors, but can prolong turnaround time. We describe new technology, which incorporates exhaustive sectioning, 3-dimensional reconstruction, and virtual microscopy, that may eliminate these problems by enabling pathologists to rapidly examine entire specimens and convert poorly oriented mucosa to well-oriented mucosa.

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