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Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery.

  • Author(s): Coussens, Nathan
  • Sittampalam, G
  • Guha, Rajarshi
  • Brimacombe, Kyle
  • Grossman, Abigail
  • Chung, Thomas
  • Weidner, Jeffrey
  • Riss, Terry
  • Trask, O
  • Auld, Douglas
  • Dahlin, Jayme
  • Devanaryan, Viswanath
  • Foley, Timothy
  • McGee, James
  • Kahl, Steven
  • Kales, Stephen
  • Arkin, Michelle
  • Baell, Jonathan
  • Bejcek, Bruce
  • Gal-Edd, Neely
  • Glicksman, Marcie
  • Haas, Joseph
  • Iversen, Philip
  • Hoeppner, Marilu
  • Lathrop, Stacy
  • Sayers, Eric
  • Liu, Hanguan
  • Trawick, Bart
  • McVey, Julie
  • Lemmon, Vance
  • Li, Zhuyin
  • McManus, Owen
  • Minor, Lisa
  • Napper, Andrew
  • Wildey, Mary
  • Pacifici, Robert
  • Chin, William
  • Xia, Menghang
  • Xu, Xin
  • Lal-Nag, Madhu
  • Hall, Matthew
  • Michael, Sam
  • Inglese, James
  • Simeonov, Anton
  • Austin, Christopher
  • et al.

Published Web Location

https://doi.org/10.1111/cts.12570
Abstract

The Assay Guidance Manual (AGM) is an eBook of best practices for the design, development, and implementation of robust assays for early drug discovery. Initiated by pharmaceutical company scientists, the manual provides guidance for designing a testing funnel of assays to identify genuine hits using high-throughput screening (HTS) and advancing them through preclinical development. Combined with a workshop/tutorial component, the overall goal of the AGM is to provide a valuable resource for training translational scientists.

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