Exercise activates the endocannabinoid system.
- Author(s): Sparling, PB;
- Giuffrida, A;
- Piomelli, D;
- Rosskopf, L;
- Dietrich, A
- et al.
Published Web Locationhttps://doi.org/10.1097/00001756-200312020-00015
Extensive documentation exists showing that exercise induces analgesia and sedation. Despite decades of research attempting to explicate a neurochemical basis for these phenomena, the mechanism underlying these changes is unknown. Using trained male college students running on a treadmill or cycling on a stationary bike for 50 min at 70-80% of maximum heart rate, we report here the first evidence that exercise of moderate intensity activates the endocannabinoid system, suggesting a new mechanism for exercise-induced analgesia and possibly other physiological and psychological adaptations to exercise.