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Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer
- Dey, Prasenjit;
- Baddour, Joelle;
- Muller, Florian;
- Wu, Chia Chin;
- Wang, Huamin;
- Liao, Wen-Ting;
- Lan, Zangdao;
- Chen, Alina;
- Gutschner, Tony;
- Kang, Yaan;
- Fleming, Jason;
- Satani, Nikunj;
- Zhao, Di;
- Achreja, Abhinav;
- Yang, Lifeng;
- Lee, Jiyoon;
- Chang, Edward;
- Genovese, Giannicola;
- Viale, Andrea;
- Ying, Haoqiang;
- Draetta, Giulio;
- Maitra, Anirban;
- Wang, Y Alan;
- Nagrath, Deepak;
- DePinho, Ronald A
Published Web Location
https://doi.org/10.1038/nature21052Abstract
Depletion of malic enzyme 3 in pancreatic cancer cells that have a deletion of the gene for malic enzyme 2 selectively kills the cells, suggesting that the enzyme might represent a therapeutic target for this subset of cancers.
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