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Purified and specific cytoplasmic pollen extract: a non-hormonal alternative for the treatment of menopausal symptoms.

  • Author(s): Genazzani, Andrea
  • Panay, Nick
  • Simoncini, Tommaso
  • Depypere, Herman
  • Mueck, Alfred
  • Egarter, Christian
  • Biglia, Nicoletta
  • Fait, Tomas
  • Birkhaeuser, Martin
  • Skouby, Sven O
  • Brincat, Mark
  • Goldstein, Steven
  • Ruan, Xiangyan
  • Celis-Gonzales, Cuauhtémoc
  • Palacios, Santiago
  • et al.

Research into non-hormonal, alternative therapies is necessary for women for whom menopausal hormone therapy is contraindicated or for women who do not wish to take hormones. This review focuses on one such non-hormonal option, namely, purified and specific cytoplasmic pollen extract, or PureCyTonin®. This extract has been evaluated in several preclinical and clinical studies, where it demonstrated its value as a safe and non-estrogenic alternative for menopause. This review presents the beneficial effects of PureCyTonin® in the treatment of menopausal symptoms (e.g. hot flushes) in healthy women, as well as in premenstrual syndrome. We discuss the mechanism of action of PureCyTonin®, an SSRI-'like' therapy. The lack of estrogenic effect demonstrated in preclinical studies suggests that PureCyTonin® may also be a suitable option for the management of menopausal symptoms in women with breast cancer.

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