Skip to main content
eScholarship
Open Access Publications from the University of California

UCSF

UC San Francisco Previously Published Works bannerUCSF

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.

  • Author(s): Postmus, Iris;
  • Trompet, Stella;
  • Deshmukh, Harshal A;
  • Barnes, Michael R;
  • Li, Xiaohui;
  • Warren, Helen R;
  • Chasman, Daniel I;
  • Zhou, Kaixin;
  • Arsenault, Benoit J;
  • Donnelly, Louise A;
  • Wiggins, Kerri L;
  • Avery, Christy L;
  • Griffin, Paula;
  • Feng, QiPing;
  • Taylor, Kent D;
  • Li, Guo;
  • Evans, Daniel S;
  • Smith, Albert V;
  • de Keyser, Catherine E;
  • Johnson, Andrew D;
  • de Craen, Anton JM;
  • Stott, David J;
  • Buckley, Brendan M;
  • Ford, Ian;
  • Westendorp, Rudi GJ;
  • Slagboom, P Eline;
  • Sattar, Naveed;
  • Munroe, Patricia B;
  • Sever, Peter;
  • Poulter, Neil;
  • Stanton, Alice;
  • Shields, Denis C;
  • O'Brien, Eoin;
  • Shaw-Hawkins, Sue;
  • Chen, Y-D Ida;
  • Nickerson, Deborah A;
  • Smith, Joshua D;
  • Dubé, Marie Pierre;
  • Boekholdt, S Matthijs;
  • Hovingh, G Kees;
  • Kastelein, John JP;
  • McKeigue, Paul M;
  • Betteridge, John;
  • Neil, Andrew;
  • Durrington, Paul N;
  • Doney, Alex;
  • Carr, Fiona;
  • Morris, Andrew;
  • McCarthy, Mark I;
  • Groop, Leif;
  • Ahlqvist, Emma;
  • Welcome Trust Case Control Consortium;
  • Bis, Joshua C;
  • Rice, Kenneth;
  • Smith, Nicholas L;
  • Lumley, Thomas;
  • Whitsel, Eric A;
  • Stürmer, Til;
  • Boerwinkle, Eric;
  • Ngwa, Julius S;
  • O'Donnell, Christopher J;
  • Vasan, Ramachandran S;
  • Wei, Wei-Qi;
  • Wilke, Russell A;
  • Liu, Ching-Ti;
  • Sun, Fangui;
  • Guo, Xiuqing;
  • Heckbert, Susan R;
  • Post, Wendy;
  • Sotoodehnia, Nona;
  • Arnold, Alice M;
  • Stafford, Jeanette M;
  • Ding, Jingzhong;
  • Herrington, David M;
  • Kritchevsky, Stephen B;
  • Eiriksdottir, Gudny;
  • Launer, Leonore J;
  • Harris, Tamara B;
  • Chu, Audrey Y;
  • Giulianini, Franco;
  • MacFadyen, Jean G;
  • Barratt, Bryan J;
  • Nyberg, Fredrik;
  • Stricker, Bruno H;
  • Uitterlinden, André G;
  • Hofman, Albert;
  • Rivadeneira, Fernando;
  • Emilsson, Valur;
  • Franco, Oscar H;
  • Ridker, Paul M;
  • Gudnason, Vilmundur;
  • Liu, Yongmei;
  • Denny, Joshua C;
  • Ballantyne, Christie M;
  • Rotter, Jerome I;
  • Adrienne Cupples, L;
  • Psaty, Bruce M;
  • Palmer, Colin NA;
  • Tardif, Jean-Claude;
  • Colhoun, Helen M;
  • Hitman, Graham;
  • Krauss, Ronald M;
  • Wouter Jukema, J;
  • Caulfield, Mark J
  • et al.
Abstract

Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects. We validate the most promising signals in a further 22,318 statin recipients and identify two loci, SORT1/CELSR2/PSRC1 and SLCO1B1, not previously identified in GWAS. Moreover, we confirm the previously described associations with APOE and LPA. Our findings advance the understanding of the pharmacogenetic architecture of statin response.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
For improved accessibility of PDF content, download the file to your device.
Current View