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Wnt and Bmp Fit Germ Cells to a T
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https://doi.org/10.1016/j.devcel.2013.11.020Abstract
Reporting in Developmental Cell, Aramaki et al. (2013) identify T as a key mediator of primordial germ cell (PGC) specification in the embryo. Deconstruction of how Bmp and Wnt signals regulate the expression and targeting of T to regulatory elements of either mesodermal or PGC genes has implications for differentiation in vitro.
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