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Enhancement of ozone-induced lung injury by exercise

  • Author(s): Mautz, WJ
  • McClure, TR
  • Reischl, P
  • Phalen, RF
  • Crocker, TT
  • et al.
Abstract

Rats were exposed for up to 3.75 h to 0.20-0.80 ppm O3 under conditions of rest and treadmill exercise up to 30 m/min, 20% grade, to assess the importance of exposure duration, O3 concentration, and exercise on lung tissue injury. Focal lung parenchymal lesions increased in abundance and severity in response to the three variables; however, exercise was the most important. Lesion response to exercise was greater than that predicted by a simple proportion to estimated effective dose of O3. The results emphasize the importance of including exercise in assessment of possible adverse health effects of exposure to airborne pollutants. © 1985 by Hemisphere Publishing Corporation.

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