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Establishing the fundamental rules for genetic code expansion

Published Web Location

https://doi.org/10.1038/s41557-023-01243-9
Abstract

Genetic code expansion beyond α-amino acids is a major challenge, in which stitching together non-natural building blocks within the ribosome is a critical barrier. Now, the molecular determinants for the efficient incorporation of non-natural amino acids into the ribosome have been unlocked, accelerating ribosomal synthesis.

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