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A mass spectrometry–guided genome mining approach for natural product peptidogenomics
- Kersten, Roland D;
- Yang, Yu-Liang;
- Xu, Yuquan;
- Cimermancic, Peter;
- Nam, Sang-Jip;
- Fenical, William;
- Fischbach, Michael A;
- Moore, Bradley S;
- Dorrestein, Pieter C
Published Web Location
https://doi.org/10.1038/nchembio.684Abstract
Peptidic natural products are theoretically amenable to characterization by mass spectrometry, but proteomics programs are not trained to discover these compounds. A new strategy uses mass spectrometry and bioinformatics iteratively to rapidly identify both ribosomal and nonribosomal sequences, yielding multiple new compounds.
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