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Defining ADHD symptom persistence in adulthood: optimizing sensitivity and specificity
- Sibley, Margaret H;
- Swanson, James M;
- Arnold, L Eugene;
- Hechtman, Lily T;
- Owens, Elizabeth B;
- Stehli, Annamarie;
- Abikoff, Howard;
- Hinshaw, Stephen P;
- Molina, Brooke SG;
- Mitchell, John T;
- Jensen, Peter S;
- Howard, Andrea L;
- Lakes, Kimberley D;
- Pelham, William E;
- Group, the MTA Cooperative
Published Web Location
https://doi.org/10.1111/jcpp.12620Abstract
OBJECTIVE: Longitudinal studies of children diagnosed with ADHD report widely ranging ADHD persistence rates in adulthood (5-75%). This study documents how information source (parent vs. self-report), method (rating scale vs. interview), and symptom threshold (DSM vs. norm-based) influence reported ADHD persistence rates in adulthood. METHOD: Five hundred seventy-nine children were diagnosed with DSM-IV ADHD-Combined Type at baseline (ages 7.0-9.9 years) 289 classmates served as a local normative comparison group (LNCG), 476 and 241 of whom respectively were evaluated in adulthood (Mean Age = 24.7). Parent and self-reports of symptoms and impairment on rating scales and structured interviews were used to investigate ADHD persistence in adulthood. RESULTS: Persistence rates were higher when using parent rather than self-reports, structured interviews rather than rating scales (for self-report but not parent report), and a norm-based (NB) threshold of 4 symptoms rather than DSM criteria. Receiver-Operating Characteristics (ROC) analyses revealed that sensitivity and specificity were optimized by combining parent and self-reports on a rating scale and applying a NB threshold. CONCLUSION: The interview format optimizes young adult self-reporting when parent reports are not available. However, the combination of parent and self-reports from rating scales, using an 'or' rule and a NB threshold optimized the balance between sensitivity and specificity. With this definition, 60% of the ADHD group demonstrated symptom persistence and 41% met both symptom and impairment criteria in adulthood.
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