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Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein

  • Author(s): Zhang, S
  • Zhou, P
  • Wang, P
  • Li, Y
  • Jiang, L
  • Jia, W
  • Wang, H
  • Fan, A
  • Wang, D
  • Shi, X
  • Fang, X
  • Hammel, M
  • Wang, S
  • Wang, X
  • Zhang, L
  • et al.
Abstract

Zhang et al. report the structural and functional analysis of the potent MERS-CoV neutralizing antibody MERS-4. MERS-4 recognizes a unique epitope and indirectly disrupts interaction between the receptor binding domain and the receptor DPP4. This mechanism provides a valuable addition for the combined use of antibodies against MERS-CoV infection.

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