Skip to main content
Download PDF
- Main
Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin
- Okamoto, Shu-ichi;
- Pouladi, Mahmoud A;
- Talantova, Maria;
- Yao, Dongdong;
- Xia, Peng;
- Ehrnhoefer, Dagmar E;
- Zaidi, Rameez;
- Clemente, Arjay;
- Kaul, Marcus;
- Graham, Rona K;
- Zhang, Dongxian;
- Vincent Chen, H-S;
- Tong, Gary;
- Hayden, Michael R;
- Lipton, Stuart A
Published Web Location
https://doi.org/10.1038/nm.2056Abstract
In a mouse model of Huntington's disease, synaptic activation of NMDA receptors induces the formation of huntingtin-containing inclusions, rendering neurons more resistant to death in vivo and in vitro. In contrast, stimulation of extrasynaptic NMDA receptors increases neuronal vulnerability by preventing inclusion formation.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.