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Ligand–protein interactions in nuclear receptors of hormones
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https://doi.org/10.1016/s0014-5793(00)01672-0Abstract
Nuclear hormone receptors are transcription factors regulated by lipophilic ligands. These hormones bind to their nuclear receptor targets using an induced fit mechanism that triggers a large conformational change and generates the proper surface for the binding of protein coactivators. The molecular details of the various steps of this activation process or its inhibition by antagonists are now understood for several nuclear receptors.
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