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BrafV600E cooperates with Pten loss to induce metastatic melanoma

et al.

Published Web Location

https://doi.org/10.1038/ng.356
Abstract

Martin McMahon and colleagues have generated a new mouse model of metastatic melanoma by generating mice with an activating mutation of Braf and deletion of Pten. The mice show metastatic melanoma with 100% penetrance and short latency, and should serve as a useful pre-clinical model in which to evaluate new therapies.

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