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Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity
- Kraus, Daniel;
- Yang, Qin;
- Kong, Dong;
- Banks, Alexander S;
- Zhang, Lin;
- Rodgers, Joseph T;
- Pirinen, Eija;
- Pulinilkunnil, Thomas C;
- Gong, Fengying;
- Wang, Ya-chin;
- Cen, Yana;
- Sauve, Anthony A;
- Asara, John M;
- Peroni, Odile D;
- Monia, Brett P;
- Bhanot, Sanjay;
- Alhonen, Leena;
- Puigserver, Pere;
- Kahn, Barbara B
Published Web Location
https://doi.org/10.1038/nature13198Abstract
Nicotinamide N-methyltransferase (NNMT) expression is increased in white adipose tissue and liver of obese and diabetic mice, Nnmt knockdown protects against diet-induced obesity by altering the availability of adipose S-adenosylmethionine and NAD+, rendering Nnmt a novel target for treating obesity and type 2 diabetes.
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