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Open Access Publications from the University of California

Sodium-glucose Cotransporter-2 Induced Diabetic Ketoacidosis with Minimal Hyperglycemia


We present the case of a 56-year-old man with a history of type 2 diabetes mellitus who presented to the emergency department in diabetic ketoacidosis (DKA) with only a slightly elevated serum glucose. The patient was taking empagliflozin (Jardiance®), a sodium-glucose cotransporter-2 inhibitor. There are increasing reports of this unusual complication in patients taking this class of medication. Emergency physicians need to be aware of this complication, as the euglycemia and history of type 2 diabetes mellitus can make the correct diagnosis of DKA challenging.

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