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Hepatitis C Viremia and the Risk of Chronic Kidney Disease in HIV-Infected Individuals
- Lucas, Gregory M;
- Jing, Yuezhou;
- Sulkowski, Mark;
- Abraham, Alison G;
- Estrella, Michelle M;
- Atta, Mohamed G;
- Fine, Derek M;
- Klein, Marina B;
- Silverberg, Michael J;
- Gill, M John;
- Moore, Richard D;
- Gebo, Kelly A;
- Sterling, Timothy R;
- Butt, Adeel A;
- for the NA-ACCORD of the IeDEA;
- Kirk, Gregory D;
- Benson, Constance A;
- Bosch, Ronald J;
- Collier, Ann C;
- Boswell, Stephen;
- Grasso, Chris;
- Mayer, Ken;
- Hogg, Robert S;
- Harrigan, Richard;
- Montaner, Julio;
- Cescon, Angela;
- Brooks, John T;
- Buchacz, Kate;
- Gebo, Kelly A;
- Moore, Richard D;
- Carey, John T;
- Rodriguez, Benigno;
- Horberg, Michael A;
- Silverberg, Michael J;
- Horberg, Michael A;
- Thorne, Jennifer E;
- Goedert, James J;
- Jacobson, Lisa P;
- Klein, Marina B;
- Rourke, Sean B;
- Burchell, Ann;
- Rachlis, Anita R;
- Rico, Puerto;
- Hunter-Mellado, Robert F;
- Mayor, Angel M;
- Gill, M John;
- Deeks, Steven G;
- Martin, Jeffrey N;
- Patel, Pragna;
- Brooks, John T;
- Saag, Michael S;
- Mugavero, Michael J;
- Willig, James;
- Eron, Joseph J;
- Napravnik, Sonia;
- Kitahata, Mari M;
- Crane, Heidi M;
- Justice, Amy C;
- Dubrow, Robert;
- Fiellin, David;
- Sterling, Timothy R;
- Haas, David;
- Bebawy, Sally;
- Turner, Megan;
- Gange, Stephen J;
- Anastos, Kathryn;
- Moore, Richard D;
- Saag, Michael S;
- Gange, Stephen J;
- Kitahata, Mari M;
- McKaig, Rosemary G;
- Justice, Amy C;
- Freeman, Aimee M;
- Moore, Richard D;
- Freeman, Aimee M;
- Lent, Carol;
- Kitahata, Mari M;
- Van Rompaey, Stephen E;
- Crane, Heidi M;
- Webster, Eric;
- Morton, Liz;
- Simon, Brenda;
- Gange, Stephen J;
- Althoff, Keri N;
- Abraham, Alison G;
- Lau, Bryan;
- Zhang, Jinbing;
- Jing, Jerry;
- Golub, Elizabeth;
- Modur, Shari;
- Hanna, David B;
- Rebeiro, Peter;
- Wong, Cherise;
- Mendes, Adell
- et al.
Published Web Location
https://doi.org/10.1093/infdis/jit373Abstract
Background
The role of active hepatitis C virus (HCV) replication in chronic kidney disease (CKD) risk has not been clarified.Methods
We compared CKD incidence in a large cohort of HIV-infected subjects who were HCV seronegative, HCV viremic (detectable HCV RNA), or HCV aviremic (HCV seropositive, undetectable HCV RNA). Stages 3 and 5 CKD were defined according to standard criteria. Progressive CKD was defined as a sustained 25% glomerular filtration rate (GFR) decrease from baseline to a GFR < 60 mL/min/1.73 m2. We used Cox models to calculate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs).Results
A total of 52 602 HCV seronegative, 9508 HCV viremic, and 913 HCV aviremic subjects were included. Compared with HCV seronegative subjects, HCV viremic subjects were at increased risk for stage 3 CKD (adjusted HR 1.36 [95% CI, 1.26, 1.46]), stage 5 CKD (1.95 [1.64, 2.31]), and progressive CKD (1.31 [1.19, 1.44]), while HCV aviremic subjects were also at increased risk for stage 3 CKD (1.19 [0.98, 1.45]), stage 5 CKD (1.69 [1.07, 2.65]), and progressive CKD (1.31 [1.02, 1.68]).Conclusions
Compared with HIV-infected subjects who were HCV seronegative, both HCV viremic and HCV aviremic individuals were at increased risk for moderate and advanced CKD.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
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