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Microbowls with Controlled Concavity for Accurate Microscale Mass Spectrometry
Published Web Location
https://doi.org/10.1002/adma.202108194Abstract
Patterned surfaces can enhance the sensitivity of laser desorption ionization mass spectrometry by segregating and concentrating analytes, but their fabrication can be challenging. Here, a simple method to fabricate substrates patterned with micrometer-scale wells that yield more accurate and sensitive mass spectrometry measurements compared to flat surfaces is described. The wells can also concentrate and localize cells and beads for cell-based assays.
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