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Defining total-body AIDS-virus burden with implications for curative strategies
- Estes, Jacob D;
- Kityo, Cissy;
- Ssali, Francis;
- Swainson, Louise;
- Makamdop, Krystelle Nganou;
- Del Prete, Gregory Q;
- Deeks, Steven G;
- Luciw, Paul A;
- Chipman, Jeffrey G;
- Beilman, Gregory J;
- Hoskuldsson, Torfi;
- Khoruts, Alexander;
- Anderson, Jodi;
- Deleage, Claire;
- Jasurda, Jacob;
- Schmidt, Thomas E;
- Hafertepe, Michael;
- Callisto, Samuel P;
- Pearson, Hope;
- Reimann, Thomas;
- Schuster, Jared;
- Schoephoerster, Jordan;
- Southern, Peter;
- Perkey, Katherine;
- Shang, Liang;
- Wietgrefe, Stephen W;
- Fletcher, Courtney V;
- Lifson, Jeffrey D;
- Douek, Daniel C;
- McCune, Joseph M;
- Haase, Ashley T;
- Schacker, Timothy W
Published Web Location
https://doi.org/10.1038/nm.4411Abstract
Quantifying the total-body virus burden in HIV-infected individuals is necessary to understand viral persistence and guide development of cure strategies. Here, Estes et al. find a high burden of residual virus in tissues of SIV-infected monkeys and HIV-infected humans, and evidence of low-level viral replication, even under antiretroviral therapy.
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