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Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs
- Henderson, Neil C;
- Arnold, Thomas D;
- Katamura, Yoshio;
- Giacomini, Marilyn M;
- Rodriguez, Juan D;
- McCarty, Joseph H;
- Pellicoro, Antonella;
- Raschperger, Elisabeth;
- Betsholtz, Christer;
- Ruminski, Peter G;
- Griggs, David W;
- Prinsen, Michael J;
- Maher, Jacquelyn J;
- Iredale, John P;
- Lacy-Hulbert, Adam;
- Adams, Ralf H;
- Sheppard, Dean
Published Web Location
https://doi.org/10.1038/nm.3282Abstract
Dean Sheppard and his colleagues show that genetic or pharmacological inhibition of αv integrin signaling ameliorates fibrosis in several solid organs.
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