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Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment
- Kitagawa, Yohko;
- Ohkura, Naganari;
- Kidani, Yujiro;
- Vandenbon, Alexis;
- Hirota, Keiji;
- Kawakami, Ryoji;
- Yasuda, Keiko;
- Motooka, Daisuke;
- Nakamura, Shota;
- Kondo, Motonari;
- Taniuchi, Ichiro;
- Kohwi-Shigematsu, Terumi;
- Sakaguchi, Shimon
Published Web Location
https://doi.org/10.1038/ni.3646Abstract
Thymic regulatory T (Treg) precursors undergo a distinct developmental pathway. Sakaguchi and colleagues show the chromatin organizer Satb1 is required for establishing the super-enhancer chromatin landscape of Treg cell–specific signature genes before Foxp3 expression.
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