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Open Access Publications from the University of California

Frequency-domain techniques enhance optical mammography: Initial clinical results

  • Author(s): Franceschini, MA
  • Moesta, KT
  • Fantini, S
  • Gaida, G
  • Gratton, E
  • Jess, H
  • Mantulin, WW
  • Seeber, M
  • Schlag, PM
  • Kaschke, M
  • et al.

We present a novel approach to optical mammography and initial clinical results. We have designed and developed a frequency-domain (110-MHz) optical scanner that performs a transillumination raster scan of the female breast in approximately 3 min. The probing light is a dual-wavelength (690 and 810 nm, 10-mW average power), 2-mm-diameter laser beam, and the detection optical fiber is 5 mm in diameter. The ac amplitude and phase data are processed with use of an algorithm that performs edge effect corrections, thereby enhancing image contrast. This contrast enhancement results in a greater tumor detectability compared with simple light intensity images. The optical mammograms are displayed on a computer screen in real time. We present x-ray and optical mammograms from two patients with breast tumors. Our initial clinical results show that the frequency-domain scanner, even at the present stage of development, has the potential to be a useful tool in mammography.

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