Skip to main content
Download PDF
- Main
Ligand discovery from a dopamine D3 receptor homology model and crystal structure
- Carlsson, Jens;
- Coleman, Ryan G;
- Setola, Vincent;
- Irwin, John J;
- Fan, Hao;
- Schlessinger, Avner;
- Sali, Andrej;
- Roth, Bryan L;
- Shoichet, Brian K
Published Web Location
https://doi.org/10.1038/nchembio.662Abstract
A virtual screen of the GPCR D3R based on a homology model prior to publication of the crystal structure and a subsequent virtual screen based on the crystal structure of the receptor once it became available both identified new ligands with verified activities.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.