Skip to main content
eScholarship
Open Access Publications from the University of California

Novel genetic loci associated with hippocampal volume.

  • Author(s): Hibar, Derrek P
  • Adams, Hieab HH
  • Jahanshad, Neda
  • Chauhan, Ganesh
  • Stein, Jason L
  • Hofer, Edith
  • Renteria, Miguel E
  • Bis, Joshua C
  • Arias-Vasquez, Alejandro
  • Ikram, M Kamran
  • Desrivières, Sylvane
  • Vernooij, Meike W
  • Abramovic, Lucija
  • Alhusaini, Saud
  • Amin, Najaf
  • Andersson, Micael
  • Arfanakis, Konstantinos
  • Aribisala, Benjamin S
  • Armstrong, Nicola J
  • Athanasiu, Lavinia
  • Axelsson, Tomas
  • Beecham, Ashley H
  • Beiser, Alexa
  • Bernard, Manon
  • Blanton, Susan H
  • Bohlken, Marc M
  • Boks, Marco P
  • Bralten, Janita
  • Brickman, Adam M
  • Carmichael, Owen
  • Chakravarty, M Mallar
  • Chen, Qiang
  • Ching, Christopher RK
  • Chouraki, Vincent
  • Cuellar-Partida, Gabriel
  • Crivello, Fabrice
  • Den Braber, Anouk
  • Doan, Nhat Trung
  • Ehrlich, Stefan
  • Giddaluru, Sudheer
  • Goldman, Aaron L
  • Gottesman, Rebecca F
  • Grimm, Oliver
  • Griswold, Michael E
  • Guadalupe, Tulio
  • Gutman, Boris A
  • Hass, Johanna
  • Haukvik, Unn K
  • Hoehn, David
  • Holmes, Avram J
  • Hoogman, Martine
  • Janowitz, Deborah
  • Jia, Tianye
  • Jørgensen, Kjetil N
  • Karbalai, Nazanin
  • Kasperaviciute, Dalia
  • Kim, Sungeun
  • Klein, Marieke
  • Kraemer, Bernd
  • Lee, Phil H
  • Liewald, David CM
  • Lopez, Lorna M
  • Luciano, Michelle
  • Macare, Christine
  • Marquand, Andre F
  • Matarin, Mar
  • Mather, Karen A
  • Mattheisen, Manuel
  • McKay, David R
  • Milaneschi, Yuri
  • Muñoz Maniega, Susana
  • Nho, Kwangsik
  • Nugent, Allison C
  • Nyquist, Paul
  • Loohuis, Loes M Olde
  • Oosterlaan, Jaap
  • Papmeyer, Martina
  • Pirpamer, Lukas
  • Pütz, Benno
  • Ramasamy, Adaikalavan
  • Richards, Jennifer S
  • Risacher, Shannon L
  • Roiz-Santiañez, Roberto
  • Rommelse, Nanda
  • Ropele, Stefan
  • Rose, Emma J
  • Royle, Natalie A
  • Rundek, Tatjana
  • Sämann, Philipp G
  • Saremi, Arvin
  • Satizabal, Claudia L
  • Schmaal, Lianne
  • Schork, Andrew J
  • Shen, Li
  • Shin, Jean
  • Shumskaya, Elena
  • Smith, Albert V
  • Sprooten, Emma
  • Strike, Lachlan T
  • Teumer, Alexander
  • Tordesillas-Gutierrez, Diana
  • Toro, Roberto
  • Trabzuni, Daniah
  • Trompet, Stella
  • Vaidya, Dhananjay
  • Van der Grond, Jeroen
  • Van der Lee, Sven J
  • Van der Meer, Dennis
  • Van Donkelaar, Marjolein MJ
  • Van Eijk, Kristel R
  • Van Erp, Theo GM
  • Van Rooij, Daan
  • Walton, Esther
  • Westlye, Lars T
  • Whelan, Christopher D
  • Windham, Beverly G
  • Winkler, Anderson M
  • Wittfeld, Katharina
  • Woldehawariat, Girma
  • Wolf, Christiane
  • Wolfers, Thomas
  • Yanek, Lisa R
  • Yang, Jingyun
  • Zijdenbos, Alex
  • Zwiers, Marcel P
  • Agartz, Ingrid
  • Almasy, Laura
  • Ames, David
  • Amouyel, Philippe
  • Andreassen, Ole A
  • Arepalli, Sampath
  • Assareh, Amelia A
  • Barral, Sandra
  • Bastin, Mark E
  • Becker, Diane M
  • Becker, James T
  • Bennett, David A
  • Blangero, John
  • van Bokhoven, Hans
  • Boomsma, Dorret I
  • Brodaty, Henry
  • Brouwer, Rachel M
  • Brunner, Han G
  • Buckner, Randy L
  • Buitelaar, Jan K
  • Bulayeva, Kazima B
  • Cahn, Wiepke
  • Calhoun, Vince D
  • Cannon, Dara M
  • Cavalleri, Gianpiero L
  • Cheng, Ching-Yu
  • Cichon, Sven
  • Cookson, Mark R
  • Corvin, Aiden
  • Crespo-Facorro, Benedicto
  • Curran, Joanne E
  • Czisch, Michael
  • Dale, Anders M
  • Davies, Gareth E
  • De Craen, Anton JM
  • De Geus, Eco JC
  • De Jager, Philip L
  • De Zubicaray, Greig I
  • Deary, Ian J
  • Debette, Stéphanie
  • DeCarli, Charles
  • Delanty, Norman
  • Depondt, Chantal
  • DeStefano, Anita
  • Dillman, Allissa
  • Djurovic, Srdjan
  • Donohoe, Gary
  • Drevets, Wayne C
  • Duggirala, Ravi
  • Dyer, Thomas D
  • Enzinger, Christian
  • Erk, Susanne
  • Espeseth, Thomas
  • Fedko, Iryna O
  • Fernández, Guillén
  • Ferrucci, Luigi
  • Fisher, Simon E
  • Fleischman, Debra A
  • Ford, Ian
  • Fornage, Myriam
  • Foroud, Tatiana M
  • Fox, Peter T
  • Francks, Clyde
  • Fukunaga, Masaki
  • Gibbs, J Raphael
  • Glahn, David C
  • Gollub, Randy L
  • Göring, Harald HH
  • Green, Robert C
  • Gruber, Oliver
  • Gudnason, Vilmundur
  • Guelfi, Sebastian
  • Håberg, Asta K
  • Hansell, Narelle K
  • Hardy, John
  • Hartman, Catharina A
  • Hashimoto, Ryota
  • Hegenscheid, Katrin
  • Heinz, Andreas
  • Le Hellard, Stephanie
  • Hernandez, Dena G
  • Heslenfeld, Dirk J
  • Ho, Beng-Choon
  • Hoekstra, Pieter J
  • Hoffmann, Wolfgang
  • Hofman, Albert
  • Holsboer, Florian
  • Homuth, Georg
  • Hosten, Norbert
  • Hottenga, Jouke-Jan
  • Huentelman, Matthew
  • Hulshoff Pol, Hilleke E
  • Ikeda, Masashi
  • Jack, Clifford R
  • Jenkinson, Mark
  • Johnson, Robert
  • Jönsson, Erik G
  • Jukema, J Wouter
  • Kahn, René S
  • Kanai, Ryota
  • Kloszewska, Iwona
  • Knopman, David S
  • Kochunov, Peter
  • Kwok, John B
  • Lawrie, Stephen M
  • Lemaître, Hervé
  • Liu, Xinmin
  • Longo, Dan L
  • Lopez, Oscar L
  • Lovestone, Simon
  • Martinez, Oliver
  • Martinot, Jean-Luc
  • Mattay, Venkata S
  • McDonald, Colm
  • McIntosh, Andrew M
  • McMahon, Francis J
  • McMahon, Katie L
  • Mecocci, Patrizia
  • Melle, Ingrid
  • Meyer-Lindenberg, Andreas
  • Mohnke, Sebastian
  • Montgomery, Grant W
  • Morris, Derek W
  • Mosley, Thomas H
  • Mühleisen, Thomas W
  • Müller-Myhsok, Bertram
  • Nalls, Michael A
  • Nauck, Matthias
  • Nichols, Thomas E
  • Niessen, Wiro J
  • Nöthen, Markus M
  • Nyberg, Lars
  • Ohi, Kazutaka
  • Olvera, Rene L
  • Ophoff, Roel A
  • Pandolfo, Massimo
  • Paus, Tomas
  • Pausova, Zdenka
  • Penninx, Brenda WJH
  • Pike, G Bruce
  • Potkin, Steven G
  • Psaty, Bruce M
  • Reppermund, Simone
  • Rietschel, Marcella
  • Roffman, Joshua L
  • Romanczuk-Seiferth, Nina
  • Rotter, Jerome I
  • Ryten, Mina
  • Sacco, Ralph L
  • Sachdev, Perminder S
  • Saykin, Andrew J
  • Schmidt, Reinhold
  • Schmidt, Helena
  • Schofield, Peter R
  • Sigursson, Sigurdur
  • Simmons, Andrew
  • Singleton, Andrew
  • Sisodiya, Sanjay M
  • Smith, Colin
  • Smoller, Jordan W
  • Soininen, Hilkka
  • Steen, Vidar M
  • Stott, David J
  • Sussmann, Jessika E
  • Thalamuthu, Anbupalam
  • Toga, Arthur W
  • Traynor, Bryan J
  • Troncoso, Juan
  • Tsolaki, Magda
  • Tzourio, Christophe
  • Uitterlinden, Andre G
  • Hernández, Maria C Valdés
  • Van der Brug, Marcel
  • van der Lugt, Aad
  • van der Wee, Nic JA
  • Van Haren, Neeltje EM
  • van 't Ent, Dennis
  • Van Tol, Marie-Jose
  • Vardarajan, Badri N
  • Vellas, Bruno
  • Veltman, Dick J
  • Völzke, Henry
  • Walter, Henrik
  • Wardlaw, Joanna M
  • Wassink, Thomas H
  • Weale, Michael E
  • Weinberger, Daniel R
  • Weiner, Michael W
  • Wen, Wei
  • Westman, Eric
  • White, Tonya
  • Wong, Tien Y
  • Wright, Clinton B
  • Zielke, Ronald H
  • Zonderman, Alan B
  • Martin, Nicholas G
  • Van Duijn, Cornelia M
  • Wright, Margaret J
  • Longstreth, WT
  • Schumann, Gunter
  • Grabe, Hans J
  • Franke, Barbara
  • Launer, Lenore J
  • Medland, Sarah E
  • Seshadri, Sudha
  • Thompson, Paul M
  • Ikram, M Arfan
  • et al.
Abstract

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg=-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
Current View