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The validity, stability, and utility of measuring uric acid in saliva

et al.

Published Web Location

https://doi.org/10.2217/bmm-2017-0336
Creative Commons 'BY' version 4.0 license
Abstract

Aim

Serum uric acid (UA) is associated with many health conditions, including kidney, cardiovascular, and metabolic disorders. We examined the validity and stability of salivary UA as a noninvasive measure of serum UA.

Materials & methods

Using serum and salivary UA data from healthy adults (n = 99), we examined the UA serum-saliva correlation, and UA associations with adiponectin and C-reactive protein. Using longitudinal data from young adults (n = 182), we examined salivary UA stability.

Results

We found robust positive serum-saliva correlations for UA. UA and adiponectin were inversely related in serum and saliva. Salivary UA was relatively stable; 62-66% of variance could be attributed to a latent trait-like component.

Conclusion

Salivary UA may be an important biomarker indexing health and disease risk.

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