Skip to main content
The validity, stability, and utility of measuring uric acid in saliva
Abstract
Aim
Serum uric acid (UA) is associated with many health conditions, including kidney, cardiovascular, and metabolic disorders. We examined the validity and stability of salivary UA as a noninvasive measure of serum UA.Materials & methods
Using serum and salivary UA data from healthy adults (n = 99), we examined the UA serum-saliva correlation, and UA associations with adiponectin and C-reactive protein. Using longitudinal data from young adults (n = 182), we examined salivary UA stability.Results
We found robust positive serum-saliva correlations for UA. UA and adiponectin were inversely related in serum and saliva. Salivary UA was relatively stable; 62-66% of variance could be attributed to a latent trait-like component.Conclusion
Salivary UA may be an important biomarker indexing health and disease risk.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.