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Nanoparticle‐Programmed Self‐Destructive Neural Stem Cells for Glioblastoma Targeting and Therapy
- Cheng, Yu;
- Morshed, Ramin;
- Cheng, Shih‐Hsun;
- Tobias, Alex;
- Auffinger, Brenda;
- Wainwright, Derek A;
- Zhang, Lingjiao;
- Yunis, Catherine;
- Han, Yu;
- Chen, Chin‐Tu;
- Lo, Leu‐Wei;
- Aboody, Karen S;
- Ahmed, Atique U;
- Lesniak, Maciej S
Published Web Location
https://doi.org/10.1002/smll.201301111Abstract
A 3-step glioblastoma-tropic delivery and therapy method using nanoparticle programmed self-destructive neural stem cells (NSCs) is demonstrated in vivo: 1) FDA-approved NSCs for clinical trials are loaded with pH-sensitive MSN-Dox; 2) the nanoparticle conjugates provide a delayed drug-releasing mechanism and allow for NSC migration towards a distant tumor site; 3) NSCs eventually undergo cell death and release impregnated MSN-Dox, which subsequently induces toxicity towards surrounding glioma cells.
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