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Alanine scan reveals modifiable residues in teixobactin

Published Web Location

https://doi.org/10.1039/c7cc03415f
Abstract

An alanine scan of Lys10-teixobactin reveals that a cationic residue at position 10 is not necessary for antibiotic activity and that position 3 tolerates substitution without loss of activity. An unexpected correlation between poor aqueous solubility and better antibiotic activity of the teixobactin analogues is observed.

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