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Open Access Publications from the University of California

Inferring a network from dynamical signals at its nodes.

  • Author(s): Weistuch, Corey
  • Agozzino, Luca
  • Mujica-Parodi, Lilianne R
  • Dill, Ken A
  • et al.

We give an approximate solution to the difficult inverse problem of inferring the topology of an unknown network from given time-dependent signals at the nodes. For example, we measure signals from individual neurons in the brain, and infer how they are inter-connected. We use Maximum Caliber as an inference principle. The combinatorial challenge of high-dimensional data is handled using two different approximations to the pairwise couplings. We show two proofs of principle: in a nonlinear genetic toggle switch circuit, and in a toy neural network.

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