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Age-related myelin degradation burdens the clearance function of microglia during aging
- Safaiyan, Shima;
- Kannaiyan, Nirmal;
- Snaidero, Nicolas;
- Brioschi, Simone;
- Biber, Knut;
- Yona, Simon;
- Edinger, Aimee L;
- Jung, Steffen;
- Rossner, Moritz J;
- Simons, Mikael
Published Web Location
https://doi.org/10.1038/nn.4325Abstract
Safaiyan et al. demonstrate that myelin fragments progressively pinch off from aged myelin sheaths and are taken up and cleared by microglia. Age-associated myelin breakdown is substantial and saturates the degradative capacities of microglia, leading to lysosomal storage and an immune activation in microglia with time.
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