Rhodium(I)-Catalyzed Intermolecular Hydroacylation of α-Keto Amides and Isatins with Non-Chelating Aldehydes
- Author(s): Kou, KGM
- Longobardi, LE
- Dong, VM
- et al.
Published Web Locationhttps://doi.org/10.1002/adsc.201500313
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. The application of the bidentate, electron-rich bisphosphine ligand, 1,3-bis(dicyclohexyl)phosphine-propane (dcpp), in rhodium(I)-catalyzed intermolecular ketone hydroacylation is herein described. Isatins and α-keto amides are shown to undergo hydroacylation with a variety of non-chelating linear and branched aliphatic aldehydes. Also reported is the synthesis of new bidentate chiral phosphine ligands, and their application in hydroacylation is discussed.
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