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Rhodium(I)‐Catalyzed Intermolecular Hydroacylation of α‐Keto Amides and Isatins with Non‐Chelating Aldehydes
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https://doi.org/10.1002/adsc.201500313Abstract
The application of the bidentate, electron-rich bisphosphine ligand, 1,3-bis(dicyclohexyl)phosphine-propane (dcpp), in rhodium(I)-catalyzed intermolecular ketone hydroacylation is herein described. Isatins and α-keto amides are shown to undergo hydroacylation with a variety of non-chelating linear and branched aliphatic aldehydes. Also reported is the synthesis of new bidentate chiral phosphine ligands, and their application in hydroacylation is discussed.
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