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Urine Tenofovir Levels Measured Using a Novel Immunoassay Predict Human Immunodeficiency Virus Protection
- Stalter, Randy M;
- Baeten, Jared M;
- Donnell, Deborah;
- Spinelli, Matthew A;
- Glidden, David V;
- Rodrigues, Warren C;
- Wang, Guohong;
- Vincent, Michael;
- Mugo, Nelly;
- Mujugira, Andrew;
- Marzinke, Mark;
- Hendrix, Craig;
- Gandhi, Monica;
- Celum, Connie;
- Baeten, Jared M;
- Donnell, Deborah;
- Coombs, Robert W;
- Lingappa, Jairam R;
- McElrath, M Juliana;
- Fife, Kenneth H;
- Were, Edwin;
- Tumwesigye, Elioda;
- Ndase, Patrick;
- Katabira, Elly;
- Katabira, Elly;
- Ronald, Allan;
- Bukusi, Elizabeth;
- Cohen, Craig R;
- Wangisi, Jonathan;
- Campbell, James D;
- Tappero, Jordan W;
- Kiarie, James;
- Farquhar, Carey;
- John-Stewart, Grace;
- Mugo, Nelly R;
- Ngure, Kenneth;
- Campbell, James D;
- Tappero, Jordan W;
- Wangisi, Jonathan
- et al.
Published Web Location
https://doi.org/10.1093/cid/ciaa785Abstract
New tools are needed to support PrEP adherence for individuals at risk for HIV, including those that enable provision of real-time feedback. In a large, completed PrEP trial, adequate urine tenofovir levels measured by a novel immunoassay predicted HIV protection and showed good sensitivity and specificity for detectable plasma tenofovir.
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