Kansagra, Akash P; Mabray, Marc C; Ferriero, Donna M; Barkovich, A James; Xu, Duan; Hess, Christopher P

doi:10.1016/j.clinimag.2016.05.009

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Microstructural maturation of white matter tracts in encephalopathic neonates

2016

Published Web Location

https://doi.org/10.1016/j.clinimag.2016.05.009

Abstract

Purpose

This study aims to apply neurite orientation dispersion and density imaging (NODDI) to measure white matter microstructural features during early development.

Methods

NODDI parameters were measured in twelve newborns and thirteen 6-month infants, all with perinatal clinical encephalopathy.

Results

Between 0 and 6 months, there were significant differences in fractional anisotropy (FA) for all tracts; in neurite density for internal capsules, optic radiations, and splenium; and in orientation dispersion for anterior limb of internal capsule and optic radiations. There were no appreciable differences in NODDI parameters related to outcome.

Conclusion

NODDI may allow more detailed characterization of microstructural maturation than FA.

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