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K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

Published Web Location

https://doi.org/10.1038/nature12796
Abstract

Small molecules are developed that irreversibly bind to the common G12C mutant of K-Ras but not the wild-type protein; crystallographic studies reveal the formation of an allosteric pocket that is not apparent in previous Ras studies, and the small molecules shift the affinity of K-Ras to favour GDP over GTP.

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