Skip to main content
Download PDF
- Main
Lipidated Peptidomimetics with Improved Antimicrobial Activity
- Hu, Yaogang;
- Amin, Mohamad Nassir;
- Padhee, Shruti;
- Wang, Rongsheng E;
- Qiao, Qiao;
- Bai, Ge;
- Li, Yaqong;
- Mathew, Archana;
- Cao, Chuanhai;
- Cai, Jianfeng
Published Web Location
https://doi.org/10.1021/ml3001215Abstract
We report a series of lipidated α-AApeptides that mimic the structure and function of natural antimicrobial lipopeptides. Several short lipidated α-AApeptides show broad-spectrum activity against a range of clinically related Gram-positive and Gram-negative bacteria as well as fungus. Their antimicrobial activity and selectivity are comparable or even superior to the clinical candidate pexiganan as well as previously reported linear α-AApeptides. The further development of lipidated α-AApeptides will lead to a new class of antibiotics to combat drug resistance.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.