Skip to main content
Download PDF
- Main
Metabolic gatekeeper function of B-lymphoid transcription factors
- Chan, Lai N;
- Chen, Zhengshan;
- Braas, Daniel;
- Lee, Jae-Woong;
- Xiao, Gang;
- Geng, Huimin;
- Cosgun, Kadriye Nehir;
- Hurtz, Christian;
- Shojaee, Seyedmehdi;
- Cazzaniga, Valeria;
- Schjerven, Hilde;
- Ernst, Thomas;
- Hochhaus, Andreas;
- Kornblau, Steven M;
- Konopleva, Marina;
- Pufall, Miles A;
- Cazzaniga, Giovanni;
- Liu, Grace J;
- Milne, Thomas A;
- Koeffler, H Phillip;
- Ross, Theodora S;
- Sánchez-García, Isidro;
- Borkhardt, Arndt;
- Yamamoto, Keith R;
- Dickins, Ross A;
- Graeber, Thomas G;
- Müschen, Markus
Published Web Location
https://doi.org/10.1038/nature21076Abstract
The B-lymphoid transcription factors PAX5 and IKZF1 restrict the supply of glucose and energy to B cells to levels that are not enough to fuel a driver-oncogene, thereby acting as tumour suppressors and sensitizing acute lymphoblastic leukaemia B cells to glucocorticoid therapy.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.