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Structural imprints in vivo decode RNA regulatory mechanisms
- Spitale, Robert C;
- Flynn, Ryan A;
- Zhang, Qiangfeng Cliff;
- Crisalli, Pete;
- Lee, Byron;
- Jung, Jong-Wha;
- Kuchelmeister, Hannes Y;
- Batista, Pedro J;
- Torre, Eduardo A;
- Kool, Eric T;
- Chang, Howard Y
Published Web Location
https://doi.org/10.1038/nature14263Abstract
The single-stranded nature of RNAs synthesized in the cell gives them great scope to form different structures, but current methods to measure RNA structure in vivo are limited; now, a new methodology allows researchers to examine all four nucleotides in mouse embryonic stem cells.
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