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Targeting Mitochondrial DNA with a Platinum-Based Anticancer Agent
- Wisnovsky, Simon P;
- Wilson, Justin J;
- Radford, Robert J;
- Pereira, Mark P;
- Chan, Maria R;
- Laposa, Rebecca R;
- Lippard, Stephen J;
- Kelley, Shana O
Published Web Location
https://doi.org/10.1016/j.chembiol.2013.08.010Abstract
An analog of the anticancer drug cisplatin (mtPt) was delivered to mitochondria of human cells using a peptide specifically targeting this organelle. mtPt induces apoptosis without damaging nuclear DNA, indicating that mtDNA damage is sufficient to mediate the activity of a platinum-based chemotherapeutic. This study demonstrates the specific delivery of a platinum drug to mitochondria and investigates the effects of directing this agent outside the nucleus.
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