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Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults
- Sorrells, Shawn F;
- Paredes, Mercedes F;
- Cebrian-Silla, Arantxa;
- Sandoval, Kadellyn;
- Qi, Dashi;
- Kelley, Kevin W;
- James, David;
- Mayer, Simone;
- Chang, Julia;
- Auguste, Kurtis I;
- Chang, Edward F;
- Gutierrez, Antonio J;
- Kriegstein, Arnold R;
- Mathern, Gary W;
- Oldham, Michael C;
- Huang, Eric J;
- Garcia-Verdugo, Jose Manuel;
- Yang, Zhengang;
- Alvarez-Buylla, Arturo
Published Web Location
https://doi.org/10.1038/nature25975Abstract
Recruitment of young neurons to the hippocampus decreases rapidly during the first years of life, and neurogenesis does not continue, or is extremely rare, in the adult human brain.
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