- Main
The Integrated Genomic Landscape of Thymic Epithelial Tumors
- Radovich, Milan;
- Pickering, Curtis R;
- Felau, Ina;
- Ha, Gavin;
- Zhang, Hailei;
- Jo, Heejoon;
- Hoadley, Katherine A;
- Anur, Pavana;
- Zhang, Jiexin;
- McLellan, Mike;
- Bowlby, Reanne;
- Matthew, Thomas;
- Danilova, Ludmila;
- Hegde, Apurva M;
- Kim, Jaegil;
- Leiserson, Mark DM;
- Sethi, Geetika;
- Lu, Charles;
- Ryan, Michael;
- Su, Xiaoping;
- Cherniack, Andrew D;
- Robertson, Gordon;
- Akbani, Rehan;
- Spellman, Paul;
- Weinstein, John N;
- Hayes, D Neil;
- Raphael, Ben;
- Lichtenberg, Tara;
- Leraas, Kristen;
- Zenklusen, Jean Claude;
- Network, The Cancer Genome Atlas;
- Ally, Adrian;
- Appelbaum, Elizabeth L;
- Auman, J Todd;
- Balasundaram, Miruna;
- Balu, Saianand;
- Behera, Madhusmita;
- Beroukhim, Rameen;
- Berrios, Mario;
- Blandino, Giovanni;
- Bodenheimer, Tom;
- Bootwalla, Moiz S;
- Bowen, Jay;
- Brooks, Denise;
- Carcano, Flavio M;
- Carlsen, Rebecca;
- Carvalho, Andre L;
- Castro, Patricia;
- Chalabreysse, Lara;
- Chin, Lynda;
- Cho, Juok;
- Choe, Gina;
- Chuah, Eric;
- Chudamani, Sudha;
- Cibulskis, Carrie;
- Cope, Leslie;
- Cordes, Matthew G;
- Crain, Daniel;
- Curley, Erin;
- Defreitas, Timothy;
- Demchok, John A;
- Detterbeck, Frank;
- Dhalla, Noreen;
- Dienemann, Hendrik;
- Edenfield, W Jeff;
- Facciolo, Francesco;
- Ferguson, Martin L;
- Frazer, Scott;
- Fronick, Catrina C;
- Fulton, Lucinda A;
- Fulton, Robert S;
- Gabriel, Stacey B;
- Gardner, Johanna;
- Gastier-Foster, Julie M;
- Gehlenborg, Nils;
- Gerken, Mark;
- Getz, Gad;
- Heiman, David I;
- Hobensack, Shital;
- Holbrook, Andrea;
- Holt, Robert A;
- Hoyle, Alan P;
- Hutter, Carolyn M;
- Ittmann, Michael;
- Jefferys, Stuart R;
- Jones, Corbin D;
- Jones, Steven JM;
- Kasaian, Katayoon;
- Kim, Jaegil;
- Kimes, Patrick K;
- Lai, Phillip H;
- Laird, Peter W;
- Lawrence, Michael S;
- Lin, Pei;
- Liu, Jia;
- Lolla, Laxmi;
- Lu, Yiling;
- Ma, Yussanne;
- Maglinte, Dennis T;
- Mallery, David;
- Mardis, Elaine R;
- Marra, Marco A;
- Martin, Julie;
- Mayo, Michael;
- Meier, Sam;
- Meister, Michael;
- Meng, Shaowu;
- Meyerson, Matthew;
- Mieczkowski, Piotr A;
- Miller, Christopher A;
- Mills, Gordon B;
- Moore, Richard A;
- Morris, Scott;
- Mose, Lisle E;
- Muley, Thomas;
- Mungall, Andrew J;
- Mungall, Karen;
- Naresh, Rashi;
- Newton, Yulia;
- Noble, Michael S;
- Owonikoko, Taofeek;
- Parker, Joel S;
- Paulaskis, Joseph;
- Penny, Robert;
- Perou, Charles M;
- Perrin, Corinne;
- Pihl, Todd;
- Radenbaugh, Amie;
- Ramalingam, Suresh;
- Ramirez, Nilsa;
- Rieker, Ralf;
- Roach, Jeffrey;
- Sadeghi, Sara;
- Saksena, Gordon;
- Schein, Jacqueline E;
- Schmidt, Heather K;
- Schumacher, Steven E;
- Shelton, Candace;
- Shelton, Troy;
- Shi, Yan;
- Shih, Juliann;
- Sica, Gabriel;
- Silveira, Henrique CS;
- Simons, Janae V;
- Sipahimalani, Payal;
- Skelly, Tara;
- Sofia, Heidi J;
- Soloway, Matthew G;
- Stuart, Joshua;
- Sun, Qiang;
- Tam, Angela;
- Tan, Donghui;
- Tarnuzzer, Roy;
- Thiessen, Nina;
- Van Den Berg, David J;
- Vasef, Mohammad A;
- Veluvolu, Umadevi;
- Voet, Doug;
- Walter, Vonn;
- Wan, Yunhu;
- Wang, Zhining;
- Warth, Arne;
- Weis, Cleo-Aron;
- Weisenberger, Daniel J;
- Wilkerson, Matthew D;
- Wise, Lisa;
- Wong, Tina;
- Wu, Hsin-Ta;
- Wu, Ye;
- Yang, Liming;
- Zhang, Jiashan;
- Zmuda, Erik;
- Fujimoto, Junya;
- Scapulatempo-Neto, Cristovam;
- Moreira, Andre L;
- Hwang, David;
- Huang, James;
- Marino, Mirella;
- Korst, Robert;
- Giaccone, Giuseppe;
- Gokmen-Polar, Yesim;
- Badve, Sunil;
- Rajan, Arun;
- Ströbel, Philipp;
- Girard, Nicolas;
- Tsao, Ming S;
- Marx, Alexander;
- Tsao, Anne S;
- Loehrer, Patrick J
- et al.
Published Web Location
https://doi.org/10.1016/j.ccell.2018.01.003Abstract
Thymic epithelial tumors (TETs) are one of the rarest adult malignancies. Among TETs, thymoma is the most predominant, characterized by a unique association with autoimmune diseases, followed by thymic carcinoma, which is less common but more clinically aggressive. Using multi-platform omics analyses on 117 TETs, we define four subtypes of these tumors defined by genomic hallmarks and an association with survival and World Health Organization histological subtype. We further demonstrate a marked prevalence of a thymoma-specific mutated oncogene, GTF2I, and explore its biological effects on multi-platform analysis. We further observe enrichment of mutations in HRAS, NRAS, and TP53. Last, we identify a molecular link between thymoma and the autoimmune disease myasthenia gravis, characterized by tumoral overexpression of muscle autoantigens, and increased aneuploidy.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
Main Content
Enter the password to open this PDF file:
-
-
-
-
-
-
-
-
-
-
-
-
-
-