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Open Access Publications from the University of California

Empagliflozin-induced Diabetic Ketoacidosis Unmasking a Type 1 Diabetes Diagnosis

  • Author(s): Ray, Gretchen M.
  • Rodriguez, Chelsea
  • Schulman, Samantha
  • Sarangarm, Preeyaporn
  • Bardack, Michelle
  • Bouchonville, Matthew F.
  • et al.

Empagliflozin is a sodium glucose cotransporter-2 inhibitor that inhibits renal glucose reabsorption through an insulin-independent mechanism. This class of drugs is used in the management of type 2 diabetes. A 49-year-old female with type 2 diabetes treated with empagliflozin presented to the emergency department in diabetic ketoacidosis (DKA). This case report details the series of events leading to the diagnosis of drug-induced DKA, which led to a change in the patient’s diagnosis from type 2 diabetes to type 1 diabetes.

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