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Diagnostic assay to assist clinical decisions for unclassified severe combined immune deficiency
- Bifsha, Panojot;
- Leiding, Jennifer W;
- Pai, Sung-Yun;
- Colamartino, Aurelien BL;
- Hartog, Nicholas;
- Church, Joseph A;
- Oshrine, Benjamin R;
- Puck, Jennifer M;
- Markert, M Louise;
- Haddad, Elie
Published Web Location
https://doi.org/10.1182/bloodadvances.2020001736Abstract
Key Points 3D organoid T-cell differentiation from a few hundred peripheral blood CD34+ cells was successfully achieved. 3D organoid T-cell differentiation could help physicians distinguish intrinsic from extrinsic defects underlying a clinical SCID phenotype.
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