CHANCE: comprehensive software for quality control and
validation of ChIP-seq data
- Author(s): Diaz, Aaron
- Nellore, Abhinav
- Song, Jun S
- et al.
Published Web Locationhttp://dx.doi.org/10.1186/gb-2012-13-10-r98
Abstract ChIP-seq is a powerful method for obtaining genome-wide maps of protein-DNA interactions and epigenetic modifications. CHANCE (CHip-seq ANalytics and Confidence Estimation) is a standalone package for ChIP-seq quality control and protocol optimization. Our user-friendly graphical software quickly estimates the strength and quality of immunoprecipitations, identifies biases, compares the user's data with ENCODE's large collection of published datasets, performs multi-sample normalization, checks against quantitative PCR-validated control regions, and produces informative graphical reports. CHANCE is available at https://github.com/songlab/chance.