CHANCE: comprehensive software for quality control and validation of ChIP-seq data
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CHANCE: comprehensive software for quality control and validation of ChIP-seq data

  • Author(s): Diaz, Aaron
  • Nellore, Abhinav
  • Song, Jun S
  • et al.
Abstract

Abstract ChIP-seq is a powerful method for obtaining genome-wide maps of protein-DNA interactions and epigenetic modifications. CHANCE (CHip-seq ANalytics and Confidence Estimation) is a standalone package for ChIP-seq quality control and protocol optimization. Our user-friendly graphical software quickly estimates the strength and quality of immunoprecipitations, identifies biases, compares the user's data with ENCODE's large collection of published datasets, performs multi-sample normalization, checks against quantitative PCR-validated control regions, and produces informative graphical reports. CHANCE is available at https://github.com/songlab/chance.

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