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The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance
- Waterfield, Michael;
- Khan, Imran S;
- Cortez, Jessica T;
- Fan, Una;
- Metzger, Todd;
- Greer, Alexandra;
- Fasano, Kayla;
- Martinez-Llordella, Marc;
- Pollack, Joshua L;
- Erle, David J;
- Su, Maureen;
- Anderson, Mark S
Published Web Location
https://doi.org/10.1038/ni.2820Abstract
The transcriptional regulator Aire is required for central tolerance, but how it manages to target tissue-specific genes is unclear. Anderson and colleagues show that Aire achieves such targeting by coopting the ATF7ip-MBD1 repressor complex.
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