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Inhibition of epidermal growth factor receptor restores decidualization markers in stromal fibroblasts from women with endometriosis

  • Author(s): Erikson, DW;
  • Chen, JC;
  • Piltonen, TT;
  • Conti, M;
  • Irwin, JC;
  • Giudice, LC
  • et al.
Abstract

Purpose: Decidualization comprises specific biochemical and morphological changes in uterine endometrium essential for establishment of pregnancy. This process is abnormal in women with endometriosis, a disorder in which endometrial-like tissue is present outside the uterus. The aim of this study was to restore cAMP-induced decidualization marker expression in endometrial stromal fibroblasts from women with endometriosis by using chemical inhibitors to PI3K/AKT/mammalian target of rapamycin (mTOR), mitogen-activated protein kinase (MAPK) and epidermal growth factor receptor (EGFR) signaling pathways in vitro.

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