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Sparse PCA corrects for cell type heterogeneity in epigenome-wide association studies
- Rahmani, Elior;
- Zaitlen, Noah;
- Baran, Yael;
- Eng, Celeste;
- Hu, Donglei;
- Galanter, Joshua;
- Oh, Sam;
- Burchard, Esteban G;
- Eskin, Eleazar;
- Zou, James;
- Halperin, Eran
Published Web Location
https://doi.org/10.1038/nmeth.3809Abstract
Principal component analysis on a subset of differentially methylated regions in a mixture of cell types is the basis of ReFACTor, a program to account for heterogeneity in epigenome-wide association studies (EWAS).
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